A second envelope glycoprotein mediates neutralization of a pestivirus, hog cholera virus.

نویسندگان

  • E Weiland
  • R Ahl
  • R Stark
  • F Weiland
  • H J Thiel
چکیده

Several monoclonal antibodies (MAbs) raised against hog cholera virus (HCV) reacted with the HCV structural glycoprotein gp44/48 and neutralized the virus. The presence of HCV gp44/48 on the viral surface was directly demonstrated by immunogold electron microscopy. Eight anti-HCV gp44/48 MAbs were tested by immunoperoxidase assay against a panel of pestivirus strains. Each MAb showed a distinct pattern of reactivity with HCV strains. It is suggested that the MAbs are well suited for epidemiological investigations of HCV outbreaks.

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عنوان ژورنال:
  • Journal of virology

دوره 66 6  شماره 

صفحات  -

تاریخ انتشار 1992